Objective:
@EN The purpose of this study was to evaluate the usefulness of urapidil in deliberated hypotension to compared with phentolamine
@ES Method and Materials:
@EN twelve mongrel dogs(14-23kg) were randomly divided into urapidil group(14-23kg) were randomly divided into urapidil group(n=6) and phentolamine group(n=6). All dogs received general anesthesia. Immediately before inducing hypotension,
complete
hemodynamic parameters and arterial bloo gas variables were recorded and at each time of 5min, 20min, 40min, and 60min after administration of urapidil and phentolamine, above variables were recorded.
@ES Results:
@EN The reducting effect of blood pressure was similar between urapidil and phentolamine at the time of 5min, 20min after administration. In urapidil group, the change of heart rate was not significant but that was significantly increased in
phentolamine gropu. Cardiac output had been well maintained in urapidil group but increased slightly in phentolamine group. Arterial blood gas analysis showed no significant changes in both groups.
@ES Conclusion:
@EN Treatment of urapidil or phentolamine lowered blood pressure, but urapidil group showed less increase of heart rate to compare with phentolamine group. So we suggest that urapidil is a useful drug for deliberated hypotension.
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